Abstract
The BINOL ligand ( R)- 2 that contains bulky 3,3′-tertiaryalkyl groups shows improved catalytic properties over the previously reported 3,3′-substituted BINOL ligands in the asymmetric alkyne addition to aromatic aldehydes. It catalyzes the phenylacetylene addition to aromatic aldehydes with high enantioselectivity (86–94% ee) and good yields without using Ti(O i Pr) 4 and a Lewis base additive. The catalytic properties of several analogs of ( R)- 2 in the asymmetric alkyne addition to aldehydes have also been studied.
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