Abstract
Vitiligo is a disease characterized by sharply limited white macular depigmentation as a result of melanocyte loss. Disease is divided into three types according to prevalence and localization as localized, general and universal. Etiology of vitiligo is unknown, but clearly shows a complex structure. Genetic predisposition, stress, many influencing factors such as systemic diseases and physical trauma causes vitiligo. In our study, MYG1 gene rs1465073 (-119C/ G) and CTLA4 gene rs231775 (49A/G) polymorphisms were evaluated in 106 patients diagnosed with vitiligo and 97 controls. Genotyping was performed using real time PCR method. There is no statistically significant differences between patients and controls in terms of allele frequencies of MYG1gene rs1465073 and ve CTLA4 gene rs231775 polymorphisms. Beside, there is no statistically significant differences between patients and controls in terms of genotype frequencies of CTLA4 gene rs231775 polymorphism. On contrary to this there is statistically significant differences between patients and controls in terms of genotype frequencies of MYG1gene rs1465073 polymorphism.In conclusion, consistent with the literature data, there is a significant association between MYG1gene rs1465073 polymorphism and vitiligo. But there is no directly association between CTLA4 gene rs231775 polymorphism and vitiligo.Journal of Advances in Internal Medicine 2016;05(01):1-5
Highlights
Vitiligo is a common acquired depigmentation disorder of the skin manifested by the presence of white macules.[1]
The researchers are trying to explain the pathogenesis of vitiligo with different hypotheses
The three main prevailing theories of pathogenesis of vitiligo are centered on neurochemical, autoimmune and oxidative stress aspects, but none of these hyphotheses explain the entire spectrum of the vitiligo disorder.[25]
Summary
Vitiligo is a common acquired depigmentation disorder of the skin manifested by the presence of white macules.[1] Vitiligo is varies from 0.2% to 1% in various global populations without sex predilection.[3] Njoo and Westerhof[4] reported that the etiology of vitiligo is still unknown, but genetic factors, oxidative divided clinically into two main forms, segmental vitiligo (SV) and non-segmental vitiligo respectively. The latter includes three major subsets, namely generalized vitiligo, acrofacial vitiligo, and universal vitiligo.[2] The prevalence of this disease. The genetics of vitiligo can not be explained by simple Mendelian genetics, and it is characterized by incomplete penetrance,multiple susceptibility loci, and genetic heterogeneity factors.[5]
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