1197 Optimizing a T cell-engaging bispecific antibody targeting the highly recurrent p53 R175H neoantigen via affinity maturation

Abstract

BackgroundTargeting mutation-associated neoantigens (MANAs) is a highly-cancer specific strategy to selectively eliminate cells harboring common driver mutations in genes encoding intracellular proteins such as Ras and p53.1, 2 T cell-engaging...