Abstract
Normal (N) and familial hypercholesterolemic (FHC) siblings' excretion of fecal neutral sterols (FNS) and fecal bile acids (FBA) were compared as a possible mechanism to explain the hypercholesterolemia of FHC. Fifteen children, 5 N and 10 FHC, age 7-16, were studied on two diets. Diet A contained 188 mg cholesterol per day and Diet B contained 30 mg cholesterol per day. Children were admitted for 14 days. Three pooled stool samples, three days each, were collected with two markers and analyzed for FNS and FBA by TLC and GLC techniques. In Diet A there was no difference in FBA or FNS between N and FHC siblings. In the low cholesterol diet (Diet B), there was a significant increase in FBA and FNS excretion in FHC, but not in normals. The feedback mechanism for cholesterol production was intact in FHC children. Decreased FBA or FNS excretion does not explain the hypercholesterolemia in FHC children.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
