119 Defining the role of innate immune cells in cancer immunoediting in epidermal neoplasms via longitudinal, intravital imaging

Abstract

Cancer immunoediting is a dynamic process whereby the immune system can both constrain and promote tumor development, which proceeds through three phases termed elimination, equilibrium, and escape. Although the cancer immunoediting process has set the foundation for understanding the immune system’s dual roles on cancer cells and establishing the basis for revolutionary cancer immunotherapies, very few studies have captured immunoediting in its early stages due to lack of proper mouse models. To address this deficiency, we developed a novel mouse model for fluorescent tracing of somatic, epithelial transformation to study the role of immunoediting in epithelial cancer development.