Abstract
Radiotherapy (RT) plays a pivotal role in the standard regional therapy for breast cancer, however, intrinsic or acquired resistance to radiotherapy, a barrier to yield clinical benefit, can be one of the main reasons of local recurrence or even leading to distant metastasis. Our previous work found that CD146, a transmembrane receptor protein, implicated in the acquisition of radio-resistance. However, the specific mechanism by which CD146 interacts with YAP signaling pathway and induces DNA damage response and radio-resistance remains unknown.
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