118P - Association of metastatic disease with the original tumour size at presentation in colon cancer: A large population-based retrospective study

Abstract

BackgroundThis study aimed to investigate the association of tumor size with the metastasis in colon cancer. MethodsPatients diagnosed with malignant colon cancer between January 1, 2010, and December 31, 2014, from the Surveillance, Epidemiology, and End Results (SEER) program were identified for the analysis. Patients with single metastatic colon cancer and tumor size measured in millimeters accurately were included in our study. ResultsA total of 97862 patients with malignant colon cancer were identified in the SEER database. The mean [stand deviation (SD)] tumor size of metastatic colon cancer was bigger than that of the nonmetastatic colon cancer (55.11 ± 35.62mm vs. 45.43±33.88 mm, P < 0.001). And our further analysis found that the mean [standard deviation(SD)] tumor sizes of liver metastasis, pulmonary metastasis, bone metastasis and brain metastasis were 55.20mm (36.08 mm), 55.09mm (30.47 mm), 46.72mm (34.07 mm) and 58.03mm (27.52 mm), respectively. ConclusionsColon cancer patients with bigger tumor size are associated with high risk of metastasis. Furthermore, tumor size of brain metastasis is bigger than that of liver and pulmonary metastasis, while bone metastasis is much smaller than that of liver and pulmonary metastasis. Legal entity responsible for the studyThe author. FundingHas not received any funding. DisclosureThe author has declared no conflicts of interest.