1186P - Gene Amplification of ACTN4 in Lung Cancer: A Novel Prognostic Indicator for Stage I Adenocarcinoma of The Lung

Abstract

ABSTRACT Background Even if detected at an early stage, a substantial number of lung cancers relapse after surgery. Patients with such tumors are likely to benefit from adjuvant therapy, but methods for identifying such patients have yet to be established. Methods We retrospectively analyzed multiple cohorts totaling 1744 patients who underwent resection of lung adenocarcinoma. Expression of actinin-4 protein in tumors was evaluated immunohistochemically, and copy numbers of the actinin-4 (ACTN4) gene were determined by fluorescence in situ hybridization. Results Amplification of the ACTN4 gene correlated significantly with smoking history (P = 0.02), pathological stage (P = 0.002), and histological differentiation (P Conclusions Amplification of the actinin-4 gene defines a subset of stage I lung adenocarcinoma with distinctly poor outcomes. Disclosure All authors have declared no conflicts of interest.