Abstract
The prognostic significance of the expression of NM23, Cathepsin-D, EGFR and C-erbB-2 was evaluated by immunohistochemistry on 176 cases of cervical carcinoma stage IB. All were treated by radical hysterectomy with pelvic lymphadenectomy during 1987 to 1990 and followed-up until 311294. Expression of NM23 was less common in adenocarcinoma (14/28 = 50%) than in squamous cell (97/132 = 74%) or adenosquamous cell carcinoma (13/19 = 81%). Expression of Cathepsin-D was seen in 49% of tumors with no difference between histologic types. Overexpression of EGFR was seen in 26% of squamous cell tumors but only in 4% and 6% of adeno and adenosquamous cell tumors. In univariate analysis of survival, NM23 expression was associated with a RH of 3.3 (P = 0.027), Cathepsin-D expression with a RH of 3.6 (P = 0.002), EGFR overexpression with a RH of 2.0 (P = 0.07), while c-erbB-2 expression had no prognostic significance. In multivariate analysis including tumor size, vessel invasion, grade of differentiation and tumor invasion into parametria, Cathepsin-D expression and EGFR overexpression were significant, while NM23 was of marginal significance (P = 0.07).
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