1181 GEN1042-mIgG2a, an Fc-inert mouse-human chimeric variant of GEN1042 (DuoBody®-CD40x4–1BB), exhibits in vivo antitumor activity and peripheral immune modulation

Abstract

BackgroundGEN1042 (DuoBody®-CD40x4–1BB) is an investigational, novel, bispecific antibody that combines targeting and conditional activation of CD40 and 4–1BB on immune cells. We recently reported preclinical characterization and encouraging clinical activity...