Abstract
Protein post-translational modifications form a vital component of inflammatory microenvironment and are critical in the pathogenesis of multiple skin disorders. One among them is protein deimination or citrullination, catalyzed by peptidyl-arginine deiminases (PADs). Expression of these enzymes in tightly controlled during differentiation of keratinocytes, however the regulatory elements are still unknown. Here we show that the cytokines infiltrating skin during inflammation, regulate expression of PADs.
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