1170 The prognosis of cervical cancer associated with pregnancy

Abstract

To evaluate the influence of pregnancy on the course and survival of cervical cancer (CC) we performed a matched cohort study. 44 patients with gestational CC and treated with standard oncological therapy were matched to 44 contemporary controls. Matching criteria were age, FIGO stage, tumor type, treatment modality. <h3>Results</h3> In 23 cases CC was diagnosed during pregnancy, in 21 cases within 6 months after delivery. 39 patients had an early stage of CC (8 IA, 25 IB, 6 IIA) and 5 had an advanced stage (4 IIB, 1 IIIB). For early stages the 5 year survival rate was 84.6% for both cases and controls (RR 1.00, CI 0.35–2.83). The size of the group with advanced carcinoma was too small to allow any statistical analysis. The moment at which the diagnosis was made (trimester of pregnancy or post-partum period) and mode of delivery (abdominally vs. vaginally) had no impact on survival. No differences were observed in the prevalence and type of early and late complications of standard oncological therapy (surgery and/or radiotherapy). <h3>Conclusion</h3> The prognosis of early stage CC is similar in gestational and non-gestational patients, provided standard oncological therapy is given. Due to the limited number of patients no conclusions can be drawn about advanced stage of CC. Standard therapy does not lead to increased morbidity in gestational patients and should be aimed for.