117 Longitudinal follow-up study of arterial structure in patients with severe psoriasis and treated with ustekinumab or with tumor necrosis factor alpha inhibitors

Abstract

Psoriasis vulgaris (PV) is a chronic inflammatory skin disease. Patients with severe PV have higher cardiovascular (CV) morbi-mortality compared to mild PV or general population. However, impact of biological treatments on CV parameters is unclear. The aim of this study was to investigate the differential impact of TNF inhibitors (TNFi) and ustekinumab (UST) on morphometric and functional parameters of atherosclerotic disease in severe chronic PV. In this parallel cohort monocentric study, CV parameters including aortic stiffness (AS), carotid stiffness (CS), intima media thickness (IMT) and carotid distension (CD) were prospectively assessed by high-definition ultrasound and arterial tonometry in 29 severe PV patients with increased CV risk profiles, receiving TNFi or UST.