Abstract
Atopic dermatitis (AD) is a composite disease characterized by derangement of the skin permeability barrier (SPB). Little is known on the role played by the sebaceous gland (SG) activity in the SPB integrity in AD. Our objective was to investigate lipidomics profiles of sebaceous-type and epidermal-type free fatty acids (FFAs), together with levels of squalene, cholesterol, triglycerides (TGs), and wax esters (WEs) in sebum and stratum corneum (SC) specimens obtained from seborrheic and non-seborrheic areas in healthy and AD adults.
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