1165. Risk Factors for Bloodstream Infections During Extracorporeal Membrane Oxygenation (ECMO)

Abstract

BackgroundAlthough bloodstream infections (BSIs) are important complications of ECMO, data on clinical characteristics of ECMO-associated BSIs remain limited. This study aimed to investigate clinical characteristics of ECMO-associated BSIs and evaluate the role of routine active surveillance cultures (ASCs) in predicting subsequent BSIs.MethodsWe reviewed the medical records of adult patients who received ECMO for >48 hours in 2 teaching hospitals between January 2013 and March 2019. ECMO-associated BSIs were defined as bacteremia occurring from 48 hours after ECMO initiation. ASCs for multidrug-resistant organisms were obtained from nasal, axillary, inguinal, and rectal swabs when patients were admitted to the ICUs.ResultsOverall, 28 of 110 (25.4%) patients had BSIs within the median 7 days after ECMO initiation. Table 1 shows the clinical characteristics of patients with ECMO-associated BSIs. Among BSI cases, the most common pathogens were Candida spp. (25%). Longer ECMO days (P < 0.01), steroid use (P = 0.02), and more blood transfusions (P < 0.01) were associated with BSIs. However, there was no association between the results of ASCs and subsequent pathogens of BSIs.ConclusionBSIs during ECMO were associated with longer ECMO duration, steroid use and blood transfusion. The pathogens of BSIs could not be related to ASCs. Disclosures All authors: No reported disclosures.