1164P Patient-reported outcomes in patients with advanced NSCLC before and during the COVID-19 pandemic in the German prospective CRISP Registry real-world cohort (AIO-TRK-0315)

Abstract

Patients (pts) with lung cancer under treatment have been associated with a high risk of COVID-19 infection and potentially worse outcome, but real-world data on patient-reported outcomes (PRO) are still scarce. We show pts’ characteristics and PRO before and during the COVID-19 pandemic in a representative advanced non-small cell lung cancer (NSCLC) cohort in Germany. Pts with locally advanced or metastatic NSCLC from the prospective, multicenter, observational registry CRISP (NCT02622581) who started 1st-line treatment between March 1st, 2019 and February 29th, 2020 (pre-pandemic group) and those with 1st-line treatment start between March 1st, 2020 and February 28th, 2021 (pandemic group) were included in this analysis. Quality of life was assessed by FACT-G plus lung cancer subscale, anxiety and depression by PHQ-4. Pts were asked to fill in questionnaires (QRS) at time of recruitment (baseline, T0), every 2 months (mo) until mo 12 (T1-6) and thereafter every 3 mo for up to 36 mo. Here, we evaluated QRS until T6 using descriptive statistics. Recruitment was slightly higher in the pre-pandemic (n=1616) than in the pandemic period (n=1233). PRO data were documented for 1162 pts (72%) in the pre-pandemic and for 916 (74%) in the pandemic group, with a marginally higher return rate of QRS in the pandemic group at early time points (T0-2). In both groups, almost 60% of pts were male, median age was 65-67 years. ECOG was 0 in about 30% of pts, comorbidities occurred in 85% of pts. Mean baseline total scores (for FACT-G, 70.9 for both groups; for PHQ-4, 3.6 for pre-pandemic vs. 3.5 for pandemic group) and sub scores were almost identical between samples. There were no substantial differences in the mean-change-from-baseline plots between groups. Approximately 20% of pts reported anxiety, about 25% signs of depression. These prospectively collected real-world data provide insight into characteristics and PRO of pts with advanced NSCLC prior to and during the COVID-19 pandemic. For the pts, the pandemic seems to be less of a burden than the disease itself, as there is a considerable proportion of pts with high anxiety and depression scores in both groups.