1162 – Vascular factor in the etiology and pathogenesis of alzheimer’s disease

Abstract

Introduction Vascular factor is very important in the development of AD. The research investigates the changes in the cerebral angioarchitectonics at various AD stages. Methods The research included 92 patients of which: Test Group: 47 aged 34–79 suffering from AD different stages including: • 4 with preclinical stages or high risk of disease development (TDR-0); • 15 with mild dementia (TDR-1); • 20 with moderate dementia (TDR-2); • 8 with severe dementia (TDR-3). Control Group: 45 aged 28–78 with various types of brain lesions accompanied by dementia but without Alzheimer’s disease including: • 15 with chronic cerebrovascular insufficiency of atherosclerotic genesis and moderate dementia; • 12 with severe vascular dementia; • 14 with atherosclerotic parkinsonism; • 4 with Parkinson’s disease. Each patient underwent MRI, CT, SG, REG, MUGA. Results At AD different stages, changes in angioarchitectonics and microcirculation show themselves in: • lack of expressed atherosclerotic lesions of intracranial vessels - 47 (100%) patients, • reduction of capillary bed in the temporal and frontoparietal regions - 47 (100%), • development of multiple arteriovenous shunts in the same areas - 47 (100%), • corresponding early venous shunts - 47 (100%), • abnormal development of venous trunks receiving blood from arteriovenous shunts - 42 (89.4%), • venous congestion at frontal and parietal region border - 43 (91.5%), • increased loop fromation of intracranial arteries - 37 (78.7%). Control group patients had no combination of such changes. Conclusions We named the vascular factor in AD “the discirculatory angiopathy of Alzheimer’s type” (DAAT).