1160 SMOKING AND RISK OF UROTHELIAL CELL CARCINOMA OF THE BLADDER: RESULTS FROM A CONTEMPORARY, PROSPECTIVE COHORT STUDY

Abstract

You have accessJournal of UrologyBladder Cancer: Detection and Screening1 Apr 20101160 SMOKING AND RISK OF UROTHELIAL CELL CARCINOMA OF THE BLADDER: RESULTS FROM A CONTEMPORARY, PROSPECTIVE COHORT STUDY James Hotaling, Jonathan Wright, Michael Porter, and Emily White James HotalingJames Hotaling More articles by this author , Jonathan WrightJonathan Wright More articles by this author , Michael PorterMichael Porter More articles by this author , and Emily WhiteEmily White More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.660AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Cigarette smoking is one the leading causative factors associated with urothelial cell carcinoma of the bladder (UC). A number of case-control studies have investigated the relationship between both duration of current smoking and length of time from smoking cessation with UC. Fewer prospective cohort studies have been conducted on a contemporary population. Using a large prospective cohort, we explore the relationship between current and former smoking and risk of UC. METHODS Participants in the VITamins And Lifestyle Study (VITAL) comprised the study population, which included 77,719 Washington State residents aged 50-76 years. Baseline self-administered questionnaires were completed in 2000-2002 on health history and cancer risk factors. Participants with prevalent UC were excluded. Incident UC cases were determined via linkage to the Surveillance, Epidemiology, and End Results (SEER) cancer registry through 2007. Smoking history was categorized as ever use (never, former, current); pack years smoked (quartiles of use for current and former smokers); and time since quitting in years (for former smokers). Multivariate cox regression was used to estimate the Hazard ratios (HR) for developing UC by smoking status controlling for age, gender and race. RESULTS A total of 330 incident UC cases were identified. Of those without UC, 8% were current smokers and 44% were former smokers. The risk of UC was 2-fold higher (95% CI 1.5—2.6) for former smokers and 4-fold higher (95% CI 2.9—5.8) for current smokers compared to those who never smoked. Both pack years of smoking and years since quitting were associated with the risk of developing UC (both pTrend < 0.01). Among former smokers, the 2-fold increased risk remained for all subsets of pack-years and years since quitting except for those with < 7.5 pack years of smoking. CONCLUSIONS In a contemporary, large prospective cohort, we confirm the 2-4 fold increase risk of UC in smokers, with a dose dependent effect seen for pack years smoked. The increased risk of developing UC persisted for more than 20 years after quitting smoking. Former smokers with less than 7.5 pack-years of smoking had no increased risk of bladder cancer. Seattle, WA© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e449 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information James Hotaling More articles by this author Jonathan Wright More articles by this author Michael Porter More articles by this author Emily White More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...