Abstract
Acute Graft-versus-Host Disease (GVHD) remains a major complication after allogeneic hematopoietic cell transplantation (HCT). Several publications show a potential beneficial effect of human MMSC for the treatment of refractory GVHD. The mechanism of action remains to be determined. We set out to develop an animal model that can be used to further study the effect of MMSC on GVHD. MMSC were obtained from female C57Bl/6J (H2b) mice by standard culture technique. ISCT criteria were used to confirm development of bona fide MMSC by flow cytometry and by in-vitro differentiation experiments.
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