1157 Discovery of a novel, potent small molecule inhibitors of ENPP1 enhances anti-tumor efficacy in combination with immune check inhbitors

Abstract

BackgroundThe cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) signaling pathway has led to significant innate immune responses in cancer immunotherapy. 2’3’-cGAMP, the second messenger in the cGAS-STING signaling pathway, binds...