1155 ONM-501, a polyvalent STING agonist, exhibits anti-tumor efficacy with increased tumor T-cell infiltration in mice and is well tolerated in rats and non-human primates

Abstract

BackgroundThe Stimulator of Interferon Genes (STING) plays a crucial role in the innate immune response.1 Several small molecule STING agonists have demonstrated effectiveness against cancer in preclinical models. In clinical...