1154 TIME-COURSE CHANGES IN URETHRAL FUNCTION AFTER SIMULATED BIRTH TRAUMA WITH OR WITHOUT OVARIECTOMY IN A RAT MODEL OF SNEEZE-INDUCED STRESS URINARY INCONTINENCE

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Incontinence - Evaluation & Therapy1 Apr 20111154 TIME-COURSE CHANGES IN URETHRAL FUNCTION AFTER SIMULATED BIRTH TRAUMA WITH OR WITHOUT OVARIECTOMY IN A RAT MODEL OF SNEEZE-INDUCED STRESS URINARY INCONTINENCE Takeya Kitta, Hiroshi Tanaka, Takahiko Mitsui, Yukiko Kanno, Kimihiko Moriya, Katsuya Nonomura, and Naoki Yoshimura Takeya KittaTakeya Kitta Sapporo, Japan More articles by this author , Hiroshi TanakaHiroshi Tanaka Sapporo, Japan More articles by this author , Takahiko MitsuiTakahiko Mitsui Sapporo, Japan More articles by this author , Yukiko KannoYukiko Kanno Sapporo, Japan More articles by this author , Kimihiko MoriyaKimihiko Moriya Sapporo, Japan More articles by this author , Katsuya NonomuraKatsuya Nonomura Sapporo, Japan More articles by this author , and Naoki YoshimuraNaoki Yoshimura Pittsburgh, PA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.764AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Pregnancy and vaginal child delivery are considered to be important causes of stress urinary incontinence (SUI) however the exact mechanisms by which urethral function is damaged is not well known. We performed a detailed time course evaluation of changes in the urethral continence reflex after simulated birth trauma and/or ovariectomy (OVX) in rats. METHODS Female Sprague-Dawley rats underwent bilateral OVX or sham operation. Simulated birth trauma was then induced by vaginal distension (VD) induced by balloon catheter inflation in the vagina, the timing of which was adjusted in order to perform the experiments 6 weeks after OVX. Four days, 1, 2 and 4 weeks after VD, sneeze induced urethral responses and the incidence of SUI, which was identified by fluid leakage from the urethral orifice during sneezing. Urethral responses were measured using a microtransducer catheter inserted to the middle urethra from the urethral orifice to evaluate the amplitude of urethral responses during sneezing (A-URS) and urethral baseline pressure (UBP). RESULTS Four days after VD, A-URS and UBP were significant decreased, and SUI during sneezing was seen in all rats with or without OVX (Fig. 1A & B). However, in rats without OVX, no leakage during sneezing was observed 2 weeks after VD (Fig. 1C) although A-URS was still significantly decreased up to 4 weeks after VD (Fig. 1A & B). In OVX rats, the reductions in A-URS and UBP were more pronounced in 2 and 4 weeks after VD compared to non-OVX rats (Fig. 1A & B), and sneeze-induced SUI was still seen in 5 of 8 rats (62.5%) 4 weeks after VD (Fig. 1C). CONCLUSIONS Clinically, SUI after vaginal delivery usually disappears, but often reappears during peri or post-menopausal periods in women. The current results indicate that, although SUI disappears after simulated birth trauma (VD) the impairment of striated muscle urethral reflex activity (represented by A-URS) persists and that estrogen deficiency (OVX) aggravated the damage of urethral continence mechanisms induced by simulated birth trauma, resulting in overt SUI in VD rats with OVX. Thus, the history of vaginal birth trauma could be an important contributing factor to SUI, but additional factors such as estrogen deficiency are required to fully develop SUI conditions. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e463 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Takeya Kitta Sapporo, Japan More articles by this author Hiroshi Tanaka Sapporo, Japan More articles by this author Takahiko Mitsui Sapporo, Japan More articles by this author Yukiko Kanno Sapporo, Japan More articles by this author Kimihiko Moriya Sapporo, Japan More articles by this author Katsuya Nonomura Sapporo, Japan More articles by this author Naoki Yoshimura Pittsburgh, PA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...