1151-P: Differential Associations between Plasma Lipids and Insulin Resistance in Women with and without Type 1 Diabetes

Abstract

People with type 1 diabetes (T1D) can have significant insulin resistance (IR), increasing risk for cardiovascular disease and mortality. Associations between circulating lipids and IR have been demonstrated; whether these associations differ in people with and without T1D is not well understood. We analyzed targeted plasma lipidomics in 30 premenopausal women aged 18-45 years (15 with T1D and 15 without diabetes [non-DM]) who underwent a hyperinsulinemic euglycemic clamp to measure glucose infusion rate (GIR). After stratifying by diabetes status, women were classified by tertiles of GIR, and moderated t-tests were used to compare lipids in the least IR vs. most IR tertile. Ceramide (Cer) 18:0, sphingomylelin (SM) 24:3 and SM 18:0 were higher in the most IR tertile in both groups (Table). However, 4 lipids (2 Cer, 1 SM, and 1 dihyrdoceramide [DHCer]) were higher in the most IR tertile in non-DM women, but were not significantly different in women with T1D. Eleven lipids (1 SM, 1 Cer, 1 DHCer, 1 lactosylceramide, and 7 1,2-diacylglycerols) were higher in the most IR tertile in women with T1D, but were not significantly different in non-DM women. Plasma lipid species were differentially associated with IR in women with and without T1D. Future work is needed to validate these findings in a larger sample of women and men, and to understand how these biomarkers relate to IR and lipid metabolism in T1D.View largeDownload slideView largeDownload slide DisclosureL. Pyle: None. T. B. Vigers: None. I. E. Schauer: None. B. C. Bergman: Consultant; Spouse/Partner; AstraZeneca, Eli Lilly and Company, Janssen Pharmaceuticals, Inc., Merck & Co., Inc., Novo Nordisk. J. K. Snell-bergeon: Stock/Shareholder; Self; GlaxoSmithKline plc.FundingAmerican Diabetes Association (7-13-CD-10 to J.K.S-B.); National Heart, Lung, and Blood Institute (R01HL61753, HL79611, HL113029); JDRF (17-2013-313) University of Colorado Diabetes & Endocrinology Research Center (P30DK57516); National Institutes of Health (M01-RR00051)