1151 TESTOSTERONE REPLACEMENT THERAPY WITH TESTOSTERONE UNDECANOATE LONG ACTING INTRAMUSCULAR INJECTIONS IS ASSOCIATED WITH REDUCTION IN OBESITY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation I1 Apr 20121151 TESTOSTERONE REPLACEMENT THERAPY WITH TESTOSTERONE UNDECANOATE LONG ACTING INTRAMUSCULAR INJECTIONS IS ASSOCIATED WITH REDUCTION IN OBESITY Aksam Yassin, Youssef Douaihy, Dany-Jan Yassin, Ridwan Shabsigh, and Farid Saad Aksam YassinAksam Yassin Norderstedt, Germany More articles by this author , Youssef DouaihyYoussef Douaihy Brooklyn, MA More articles by this author , Dany-Jan YassinDany-Jan Yassin Braunschweig, Germany More articles by this author , Ridwan ShabsighRidwan Shabsigh Brooklyn, MA More articles by this author , and Farid SaadFarid Saad Berlin, Germany More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1261AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Obesity and the metabolic syndrome are frequently associated with late onset hypogonadism (LOH). We sought to study the effects of testosterone replacement therapy on weight, body mass index (BMI) and waist circumference (WC) in patients with LOH. METHODS As of November 2004 130 patients with LOH (diagnosis criteria: total testosterone ≤3.5ng/dl and documented erectile dysfunction (ED) by SHIM≤21) were included in a prospective cohort study to investigate the effect of long-acting Testosterone Undecanoate (TU) 1000mg intramuscular injection. Treatment was initiated at day 1 (T1) then the second dose was administered 6 weeks after (T2). TU was injected at 3 months intervals thereafter. The parameters of weight & waist circumference were measured at baseline and at every treatment visit. Serial BMI, WC and percentage of weight change from baseline were calculated. RESULTS Weight's median follow up time was 4.7 years. The mean of cohort's weight decrease from baseline to the last visit was 14.3 kg ±8.7 [-5; 44], the mean of percentage weight loss was 13.0%±6.8 [-5.3; 34.4], the mean of BMI points decreased was 4.5±2.7 [-1.6; 13.4], and the mean waist circumference (WC) drop was 11 cm ± 6 [-13; 24]. There is a strong linear relationship between weight loss, decrease in BMI and decrease in WC and time on TU treatment (Fig 1). CONCLUSIONS Long-term treatment with TU testosterone replacement therapy results in significant reduction of all parameters of obesity. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e466-e467 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Aksam Yassin Norderstedt, Germany More articles by this author Youssef Douaihy Brooklyn, MA More articles by this author Dany-Jan Yassin Braunschweig, Germany More articles by this author Ridwan Shabsigh Brooklyn, MA More articles by this author Farid Saad Berlin, Germany More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...