Abstract
Basal cell carcinoma (BCC) is the most common skin malignancy and most frequently occurs in patients over 70 years of age. Dysregulated Hedgehog (Hh) signaling and consequent activation of GLI transcription factors is a molecular hallmark of human BCC and drives BCC-like tumor development in genetically engineered mice, which are typically studied at a young age. We examined the impact of aging on BCC tumorigenesis in young versus aged cohorts of Lgr6-CreER;R26-LSL-rtTA;tetO-GLI2A mice, in which topical 4-OHT treatment activates Cre function and rtTA expression in Lgr6+ cells and their progeny, and treatment with doxycycline leads to expression of a tetO-driven activator form of GLI2.
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