Abstract
Derangement of ceramide levels in the skin permeability barrier (SPB) is widely demonstrated in atopic dermatitis (AD). By GCMS chemometric analysis we have observed significant deficiency of sebum-specific free fatty acids (FFAs), i.e. species with odd carbon number and terminal branching, in association to sebostasis in AD sebum. To investigate the interplay between sebum and epidermal lipids, we conducted a targeted LCMS study on the sphingolipidome of the stratum corneum (SC) in sebaceous and non sebaceous areas.
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