1143 HYPOGLYCORRHACHIA ASSOCIATED WITH INTERCRANIAL HEMORRHAGE (ICH) IN THE NEWBORN

Abstract

During 1977 four newborns who developed severe hypoglycorrhachia associated with ICH were seen at the Regional Neonatal Intensive Care Unit of the University of Florida. These infants represented 20% of all infants diagnosed as having ICH in our unit during the past year. CSF cultures were negative in each case. All hemorrhages were confirmed by CAT scan. As noted in the Table the hypoglycorrhachia occurred from 3-14 days after there was clinical evidence of the bleed. In each case the hypoglycorrhachia persisted for weeks. Two babies with frequent taps had 0 mg% CSF glucose for at least three days which was associated with the peak WBC and protein elevation. We feel the decreased CSF glucose in these infants was secondary to the ICH. Similar findings have also been noted in adults after ICH. The association of hypoglycorrhachia and ICH should be taken into account when caring for high risk infants.