1142 A PROSPECTIVE STUDY OF THE EFFECT OF 5-ALPHA-REDUCTASE INHIBITOR (DUTASTERIDE) TREATMENT ON SERUM FREE TESTOSTERONE LEVEL AND AGING MALE SYMPTOMS IN JAPANESE PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation I1 Apr 20121142 A PROSPECTIVE STUDY OF THE EFFECT OF 5-ALPHA-REDUCTASE INHIBITOR (DUTASTERIDE) TREATMENT ON SERUM FREE TESTOSTERONE LEVEL AND AGING MALE SYMPTOMS IN JAPANESE PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA Takahiro Maeda, Eiji Kikuchi, Masanori Hasegawa, Gou Kaneko, Kazunobu Shinoda, Hidaka Kono, Ryuichi Mizuno, Hirohiko Nagata, Hiroshi Asanuma, Akira Miyajima, Ken Nakagawa, and Mototsugu Oya Takahiro MaedaTakahiro Maeda Tokyo, Japan More articles by this author , Eiji KikuchiEiji Kikuchi Tokyo, Japan More articles by this author , Masanori HasegawaMasanori Hasegawa Tokyo, Japan More articles by this author , Gou KanekoGou Kaneko Tokyo, Japan More articles by this author , Kazunobu ShinodaKazunobu Shinoda Tokyo, Japan More articles by this author , Hidaka KonoHidaka Kono Tokyo, Japan More articles by this author , Ryuichi MizunoRyuichi Mizuno Tokyo, Japan More articles by this author , Hirohiko NagataHirohiko Nagata Tokyo, Japan More articles by this author , Hiroshi AsanumaHiroshi Asanuma Tokyo, Japan More articles by this author , Akira MiyajimaAkira Miyajima Tokyo, Japan More articles by this author , Ken NakagawaKen Nakagawa Tokyo, Japan More articles by this author , and Mototsugu OyaMototsugu Oya Tokyo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1252AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of the present study was to clarify the effects of dutasteride on serum free testosterone levels and aging male symptoms (AMS) in patients with benign prostatic hyperplasia (BPH). METHODS This prospective study was conducted in 155 men diagnosed with moderate to severe symptomatic BPH (IPSS>7 and peak urinary flow rate of <15 mL/s) and who visited our hospital from 2009 to 2011 and opted for medical treatment of BPH by dutasteride. For all patients, AMS questionnaires and serum free testosterone were checked at baseline and after 3 months of treatment. Repeated measure ANOVA test was used to analyze the effect of dutasteride on serum free testosterone level and the AMS scores. RESULTS Dutasteride treatment led to a modest, but significantly increase in serum free testosterone level from 7.8 pg/ml to 8.9 pg/ml (P<0.01). This increase was the greatest in patients who had low baseline levels of free testosterone and the rate of appreciation exceeded 25 %. Among the evaluable 119 patients before administration of dutasteride, AMS score was 17 to 26, 27 to 36, 37 to 49, and more than 49 were in 25, 53, 27, and 14 patients, respectively. Overall, dutasteride treatment significantly increased AMS sexual subscale score, but did not affect other subscale scores. We defined symptomatic testosterone deficiency syndrome (STDS) as the serum free testosterone of less than 8.5 pg/ml and baseline AMS score of 37 or more with poor morning erection. According to the criteria, 26 patients were diagnosed as STDS. The use of dutasteride on patients with STDS increased serum free testosterone level from 6.5 pg/ml to 7.3 pg/ml (p=0.03) and significantly decrease total AMS score from 47.7 to43.0 (p=0.01), physical subscale score and sexual subscale score (P<0.01). Patients were further divided into two groups by the magnitude for improvements of total AMS scores using a cut off 3 points. Sixteen patients had AMS improvements of 3 points or more and 10 with that of less than 3 points. In patients with AMS improvements of 3 points or more, serum free testosterone level significantly increased from 6.4 pg/ml to 7.5pg/ml (p=0.02) 3months after dutasteride treatment. Meanwhile, no significant change was observed on serum free testosterone level (p=0.89) in patients with AMS improvements of less than 3 points. CONCLUSIONS Our results show that dutasteride treatment in men with BPH led to significant increase in serum free testosterone level and a significant improvement of AMS scores among those with STDS. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e463 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Takahiro Maeda Tokyo, Japan More articles by this author Eiji Kikuchi Tokyo, Japan More articles by this author Masanori Hasegawa Tokyo, Japan More articles by this author Gou Kaneko Tokyo, Japan More articles by this author Kazunobu Shinoda Tokyo, Japan More articles by this author Hidaka Kono Tokyo, Japan More articles by this author Ryuichi Mizuno Tokyo, Japan More articles by this author Hirohiko Nagata Tokyo, Japan More articles by this author Hiroshi Asanuma Tokyo, Japan More articles by this author Akira Miyajima Tokyo, Japan More articles by this author Ken Nakagawa Tokyo, Japan More articles by this author Mototsugu Oya Tokyo, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...