Abstract
Objectives The incidence of preeclampsia (PE) is markedly increased in Type 1 diabetes (T1DM); however, no specific protocols exist for risk stratification or maternal and fetal surveillance, both of which may improve outcomes in this group. Pregnancy-associated plasma protein A (PAPP-A) is a trophoblast-derived, IGF binding protein protease that increases IGF bioavailability, thus mediating trophoblast invasion of the decidua. Low maternal serum concentrations in the first trimester (PAPP-A Methods This was a retrospective cohort study in women with T1DM managed at the Royal Women’s Hospital from 2000 to 2011. It was designed to explore whether PAPP-A Results Women who underwent first trimester maternal serum screening and those who did not were well matched for baseline characteristics (advanced maternal age, parity, HbA1c, BMI, diabetic nephropathy, aspirin treatment) and for the incidence of primary outcomes (PE, SGA, PD). The significant risk factors for PE ( n = 11 of 86) on multivariate analysis were previous PE (RR 6.9, 95% CI 1.63-29.2, p = 0.009) and PAPP-A p n = 3). Conclusions PAPP-A Disclosures I. Idel: None. B. Chen: None. A. Nankervis: None. F. Cullinane: None. P. de Crespigny: None. V. Levidiotis: None. D. Liew: None. L. McMahon: None.
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