1139P A CT-based radiomic readout on the differential diagnosis of pneumonitis in stage IV non-small cell lung cancer patients treated with immune checkpoint inhibitors

Abstract

About 4-10% patients who receive immunotherapy are subjected to Immunotherapy-Induced Pneumonitis (IIP) which is a lethal complication that requires immediate interruption of immunotherapy as well as corticosteroid administration. Less than 10% of the patients also develop other types of pneumonitis (OP), (e.g. infection or radiation-induced). Making the differential diagnosis of pneumonitis (IIP vs. OP) is a challenging task due to similar radiological patterns and low incidence rates. This study was performed to develop and evaluate a prediction model using handcrafted radiomic features and their associated clinical metadata to estimate the risk of IIP in patients with stage IV Non-Small Cell Lung Cancer (NSCLC) who developed pneumonitis after immunotherapy.