Abstract
beta-1; 2.3±0.2 fmol/mg, 25%, beta-2) tissues. Beta-2 receptor densities in post-MI dogs were higher (p<0.04) in both the LAD (7.4±2 fmol/mg, 63%, beta-1; 4.3±1 fmol/mg, 37%, beta-2) and the Cx (5.6±2 fmol/mg, 54%, beta-1; 4.7±2 fmol/mg, 46%, beta-2) territories, while beta-1 receptor densities did not change. Conclusions: Beta-2 adrenergic receptor densities increase following chronic MI and comprise a larger percentage of available adrenergic receptors in canine ventricles. These data may help explain why nonselective beta-blockers tend to be more effective in post-MI clinical populations
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