Abstract
The aim of our multi-center study was to evaluate the mobilization effect of recombinant human granulocyte colony-stimulating factor(rhG-CSF; lenograstim) on peripheral blood stem cells (PSC). Dynamic movements of CD34 positive cells after 6 types of myelosuppressive chemotherapy followed by intravenous administration of rhG-CSF that started from the day at less than 500 per micro-liter of granulocyte and continued 14 days were analyzed in 59 patients with pediatric malignancy (18 of non Hodgkin's lymphoma, 17 of neuroblastoma, 10 of acute lymphoblastic leukemia and 14 of other solid tumors). The dosage of rhG-CSF was escalated from 2 to 12.5 microgram per kg and following results were obtained; the number of CD34 positive cells was correlated with that of colony funning unit-granulocyte/macrophage (r = 0.616) but not with the dosage of rhG-CSF. The type of chemotherapy and duration of granulocyte recovery affected the maximum CD34 positive cell number.
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