Abstract
Msx1 is a homeobox-containing transcription repressor that has been demonstrated to play an important role in cellular generation and regeneration processes. Our group, as well one other, has demonstrated that ectopic expression of msx1 in murine multinucleated myotubes could lead to de-differentiation of myotubes into mononucleated cells that are capable of proliferation and which possess properties of pluripotent stem cells. Previously, we have demonstrated that msx1-dedifferentiated cells (MDCs) differed from myoblasts by exhibiting reduction in the expression levels of myogenic transcription factors, such as MyoD, Myf5 and Myogenin. These cells also differed in their ability to differentiate into other mesoderm-derived cells, such as adipocytes and osteocytes. We have also demonstrated, that MDCs transcribed oct4 (expressed in undifferentiated ES and germ cells) and nucleostemin (NST), which is expressed in early multipotent stem cells and several cancer cell lines.
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