1120: Usefulness of Contrast-Enhanced Ultrasonography Using a New Contrast Agent in Differential Diagnosis of Gallbladder Polypoid Lesions

Abstract

PurposeWe studied the effectiveness and usefulness of contrast-enhanced ultrasonography using perflubutane (Sonazoid®) (Daiichi-Sankyo, Tokyo) in the differential diagnosis of gallbladder polypoid lesions.Equipments and PatientsWe treated 23 patients with polypoid lesions of the gallbladder, including 6 gallbladder cancer, 12 gallbladder benign polyp, and 5 adenomyomatosis of the gallbladder. We performed contrast-enhanced ultrasonography using a new ultrasonographic contrast agent, Sonazoid® for these patients.MethodsSonazoid® was given by bolus administration at a dosage of 0.015 mg/kg. The ultrasound system used was a SSA-770A or SSA-790A (Toshiba, Tokyo). The mechanical index was set at 0.1 to 0.3, with the focus point at the inferior part of the polypoid lesion. The early vascular phase was observed for about 30 s following administration of Sonazoid®, and appropriate observation was made for a subsequent 3 min. Thereafter, Micro Flow Imaging observed by flash replenishment image.ResultsIn gallbladder cancer, staining shows the entire tumor to be continuous with diffuse hypervascularity. We observed differences in flow image size and convection of the blood flow. For gallbladder polyp, staining was scattered and the flow image was uniform and small. Furthermore, we confirmed an image where the blood flow imaging indicated a focus of foam cells, which appeared to bridge the low echoic area gap. For adenomyomatosis of the gallbladder, we observed blood flow at the surface of the prominence and internal Rokitansky-Aschoff sinus clarity.ConclusionsContrast-enhanced ultrasonography using Sonazoid® is useful for differential diagnosis of gallbladder polypoid lesions. PurposeWe studied the effectiveness and usefulness of contrast-enhanced ultrasonography using perflubutane (Sonazoid®) (Daiichi-Sankyo, Tokyo) in the differential diagnosis of gallbladder polypoid lesions. We studied the effectiveness and usefulness of contrast-enhanced ultrasonography using perflubutane (Sonazoid®) (Daiichi-Sankyo, Tokyo) in the differential diagnosis of gallbladder polypoid lesions. Equipments and PatientsWe treated 23 patients with polypoid lesions of the gallbladder, including 6 gallbladder cancer, 12 gallbladder benign polyp, and 5 adenomyomatosis of the gallbladder. We performed contrast-enhanced ultrasonography using a new ultrasonographic contrast agent, Sonazoid® for these patients. We treated 23 patients with polypoid lesions of the gallbladder, including 6 gallbladder cancer, 12 gallbladder benign polyp, and 5 adenomyomatosis of the gallbladder. We performed contrast-enhanced ultrasonography using a new ultrasonographic contrast agent, Sonazoid® for these patients. MethodsSonazoid® was given by bolus administration at a dosage of 0.015 mg/kg. The ultrasound system used was a SSA-770A or SSA-790A (Toshiba, Tokyo). The mechanical index was set at 0.1 to 0.3, with the focus point at the inferior part of the polypoid lesion. The early vascular phase was observed for about 30 s following administration of Sonazoid®, and appropriate observation was made for a subsequent 3 min. Thereafter, Micro Flow Imaging observed by flash replenishment image. Sonazoid® was given by bolus administration at a dosage of 0.015 mg/kg. The ultrasound system used was a SSA-770A or SSA-790A (Toshiba, Tokyo). The mechanical index was set at 0.1 to 0.3, with the focus point at the inferior part of the polypoid lesion. The early vascular phase was observed for about 30 s following administration of Sonazoid®, and appropriate observation was made for a subsequent 3 min. Thereafter, Micro Flow Imaging observed by flash replenishment image. ResultsIn gallbladder cancer, staining shows the entire tumor to be continuous with diffuse hypervascularity. We observed differences in flow image size and convection of the blood flow. For gallbladder polyp, staining was scattered and the flow image was uniform and small. Furthermore, we confirmed an image where the blood flow imaging indicated a focus of foam cells, which appeared to bridge the low echoic area gap. For adenomyomatosis of the gallbladder, we observed blood flow at the surface of the prominence and internal Rokitansky-Aschoff sinus clarity. In gallbladder cancer, staining shows the entire tumor to be continuous with diffuse hypervascularity. We observed differences in flow image size and convection of the blood flow. For gallbladder polyp, staining was scattered and the flow image was uniform and small. Furthermore, we confirmed an image where the blood flow imaging indicated a focus of foam cells, which appeared to bridge the low echoic area gap. For adenomyomatosis of the gallbladder, we observed blood flow at the surface of the prominence and internal Rokitansky-Aschoff sinus clarity. ConclusionsContrast-enhanced ultrasonography using Sonazoid® is useful for differential diagnosis of gallbladder polypoid lesions. Contrast-enhanced ultrasonography using Sonazoid® is useful for differential diagnosis of gallbladder polypoid lesions.