1120 培養コラーゲン線維束のクリンプ構造に及ぼす力学的負荷の影響(OS-5 リモデリング・マイクロバイオメカニクス)

Abstract

Tendo ns and ligaments have hierarchical structures composing of collagen fascicles, fibrils, and molecules. Crimp structure of fibrils is observed in tendo ns/ligaments and collagen fascicles, and is believed to have a relation with their biomechanical properties. Tendo ns and ligaments remodel in response to mechanical stress, and change their mechanical properties. Therefore, crimp structure should change during remodeling process. To make clear this, we observed the crimp morphology of collagen fascicles cultured under various mechanical conditions. Crimp parameters (crimp angle, crimp length, and wave length) depended upon applied stress. For example, the crimp angle in the fascicle cultured under no load condition was larger than that in the control fascicle, and the angle in the fascicle cultured under cyclic load condition was lager than that of the fascicles cultured under static load condition. From these results, we can say that there is a relationship between the crimp structure of collagen fascicles and the change in the mechanical properties caused by remodeling.