Abstract
Background: The Hippo pathway (effected by the YAP/TAZ-TEAD transcriptional complex) is a major regulator of cell density and organ size, and is a major pro-growth, pro-survival pathway yet to be targeted in precision oncology. YAP/TAZ-TEAD transcription is hyperactivated by specific genetic events (e.g. YAP/TAZ oncofusions, NF2 mutations) and has been demonstrated as a key mechanism of resistance acquisition to MAPK pathway inhibition, as well as inhibition of its upstream inputs, such as EGFR and other receptor tyrosine kinases.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
