112 Identification of Non-HLA Antibodies in Ventricular Assist Device Recipients

Abstract

t is known that patients bridged to heart transplantation with ventricular assist device (VAD) have a higher incidence to develop antibodies directed against human leukocyte (HLA). Both HLA antibodies and non-HLA antibodies like major histocompatibility complex class I-related chain A (MICA) and functional autoantibodies against angiotensin type 1 receptor (AT1R) and endothelin receptor A (ETAR) are implicated in pathogenesis of acute rejection (AR) and cardiac allograft vasculopathy (CAV). Therefore, in this study we monitored HLA and non-HLA antibodies in VAD recipients (VADR) during the first year after VAD-implantation.