Abstract
Certain human cell populations have remained difficult to infect with vectors based on human adenovirus (Ad) serotype 5 due to their lack of CAR receptor. Recently, a chimeric Ad5/35 fiber, comprising of the Ad5 tail domain and the Ad35 knob and shaft domains, was created. This chimeric fiber utilizes CD46 as a receptor and displays an altered tropism from Ad5. We incorporated this chimeric fiber into a helper-dependent adenovirus vector (HD AdV) system and compared HD to E1-deleted (ED) vectors by transgene expression, cell transduction efficiency, and cytotoxicity.
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