1119 Glutamine antagonist prodrug JHU083 reprograms immunosuppressive tumor-associated macrophages to drives tumor immunity in urologic cancers

Abstract

BackgroundTumor metabolism is emerging as a regulator of immune mediated anti-tumor responses. Previously, we reported increased infiltration of immunosuppressive tumor associated macrophages (TAMs) with disease progression in prostate adenocarcinoma.1 Glutamine...