1119 EFFECTS OF CIGARETTE-SMOKE ON PLASMA TESTOSTERONE LEVEL AND ERECTION IN RATS

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research1 Apr 20111119 EFFECTS OF CIGARETTE-SMOKE ON PLASMA TESTOSTERONE LEVEL AND ERECTION IN RATS Min Gu Park, Mi Mi Oh, Jae Hyun Bae, Du Geon Moon, and Je Jong Kim Min Gu ParkMin Gu Park Seoul, Korea, Republic of More articles by this author , Mi Mi OhMi Mi Oh Seoul, Korea, Republic of More articles by this author , Jae Hyun BaeJae Hyun Bae Seoul, Korea, Republic of More articles by this author , Du Geon MoonDu Geon Moon Seoul, Korea, Republic of More articles by this author , and Je Jong KimJe Jong Kim Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.716AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of this study was to determine the actual effects of cigarette-smokie on plasma testosterone levels and erectile function in rat smoking models. METHODS For the exposure to cigarette smoke, the rats in a plastic cage had a constant influx of smoke using a specially constructed smoke generator. Twenty four Sprague Dwaly (SD) rats for the acute cigarette exposure were allocated randomly into two groups, experiment group and controls. Thirty six SD rats for the chronic cigarette smoke exposure were randomly divided into three groups, controls and experiment groups. After the exposure to smoking, the rats were submitted to electrical field stimulation of the cavernosal nerve to assess the erectile function and blood was collected to measure levels of plasma thiocyanate, testosterone, LH and FSH. Then, the histologic changes of testes were examined. RESULTS In smoking groups, plasma thiocyanate levels were significantly higher than the controls. Also, in smoking groups, mean arterial pressure (MAP) was significantly higher than the controls but, corpora cavernosal filling rate (CFR) and maximal intracavernosal pressure (MICP)/MAP were significantly lower than the controls. In hormonal studies, plasma testosterone levels of experimental groups were significantly lower than the controls in chronic smoking groups. There was a weak positive correlation between testosterone levels and CFR with statistical significance in chronic smoking groups. Histological examination of testes showed no significant change. CONCLUSIONS The results suggest that not only the vasoconstrictor effects of smoking, but also the decrease of testosterone levels after chronic smoking has some effects on erectile function in rats. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e449-e450 Peer Review Report Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Min Gu Park Seoul, Korea, Republic of More articles by this author Mi Mi Oh Seoul, Korea, Republic of More articles by this author Jae Hyun Bae Seoul, Korea, Republic of More articles by this author Du Geon Moon Seoul, Korea, Republic of More articles by this author Je Jong Kim Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...