1118-P: The Association of Ankle-Brachial Index and BMI with Pulmonary Disease in Type 1 Diabetes

Abstract

In the general population, chronic obstructive pulmonary disease (COPD) and Preserved Ratio Impaired Spirometry (PRISm) have been shown to increase mortality risk. While increased respiratory disease risk has been observed in type 1 diabetes (T1D), data on PRISm and COPD, especially in middle-age, are scarce in T1D. We thus assessed correlates of COPD and PRISm among individuals with childhood-onset T1D. Data were from the 30-year visit of the EDC study (n=162, median age/T1D duration, 56/47 years). Pulmonary function was assessed with the NDD EasyOne™ Spirometer using NHANES reference values for the predicted values. COPD was defined as Forced Expiratory Volume in 1 Second (FEV1)/Forced Vital Capacity (FVC)<0.7. PRISm was defined as FEV1% predicted<80% and FEV1/FVC≥0.7. The majority of participants were classified as having COPD (43.2%) or PRISm (25.9%), with only 30.9% having normal pulmonary function. Univariate differences by pulmonary disease status are shown in the Table. Multinomial logistic regression models were constructed to assess independent correlates of COPD and PRISm. High ABI (>1.3) was associated with greater odds of COPD (OR=4.64, 95% CI: 1.42-15.13, p=0.01) and BMI with PRISm (OR=1.10, 95% CI: 1.01-1.21, p=0.03). No other risk factor was associated with COPD or PRISm.In conclusion, high ABI and BMI appear to be independently associated with greater odds of COPD and PRISm, respectively, in T1D.View largeDownload slideView largeDownload slide DisclosureJ. Ju: None. G. L. Kinney: None. R. G. Miller: None. T. J. Orchard: None. T. Costacou: None.FundingNational Institutes of Health (DK34818)