Abstract
In this work, a recyclable and highly regioselective 1,6-hydroarylation of para-quinone methides (p-QMs) with N-heteroarenes has been developed under mild conditions. 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as a solvent plays a significant role in this transformation to achieve a wide assortment of unsymmetrical triarylmethanes with high yields and excellent regioselectivity. This novel reaction is featured a very broad substrate scope and outstanding functional group tolerance and could also be scaled-up. Moreover, this Friedel-Crafts alkylation pathway is further supported by replacing HFIP with trifluoroethanol (TFE) in the control reactions.
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