Abstract
Dexmedetomidine is a potent and selective alpha-2 agonist, and is widely used for not only an adjunct to anesthesia but also sedation during mechanical ventilation in intensive care unit. It has been reported that, although the substance does not appear to have any direct effects on the myocardial contractility, it sometimes causes a decrease in heart rate and a dose-dependent decrease in arterial blood pressure and, in rare cases, leads to cardiac arrest or shock. However, detailed mechanisms remain uncertain. We hypothesized that effects of dexmedetomidine to coronary vasoactivity and cardiac function may differ depending on postnatal ages.
Highlights
Dexmedetomidine is a potent and selective alpha-2 agonist, and is widely used for an adjunct to anesthesia and sedation during mechanical ventilation in intensive care unit
It has been reported that, the substance does not appear to have any direct effects on the myocardial contractility, it sometimes causes a decrease in heart rate and a dose-dependent decrease in arterial blood pressure and, in rare cases, leads to cardiac arrest or shock
We hypothesized that effects of dexmedetomidine to coronary vasoactivity and cardiac function may differ depending on postnatal ages
Summary
Dexmedetomidine is a potent and selective alpha-2 agonist, and is widely used for an adjunct to anesthesia and sedation during mechanical ventilation in intensive care unit. It has been reported that, the substance does not appear to have any direct effects on the myocardial contractility, it sometimes causes a decrease in heart rate and a dose-dependent decrease in arterial blood pressure and, in rare cases, leads to cardiac arrest or shock. We hypothesized that effects of dexmedetomidine to coronary vasoactivity and cardiac function may differ depending on postnatal ages
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
