Abstract
The vast majority of patients with pancreatic ductal adenocarcinoma (PDA) are not candidates for curative resection. Overall survival rates in this group of patients remain exceptionally low. Pancreatic cancer organoids are tumor models of individualized human PDA that can be rapidly generated from surgically resected tumors. Organoids simulate the full spectrum of a patient’s tumor, including stromal elements believed to be responsible for chemotherapy resistance. Hence, they can be used for testing personalized treatment strategies. For surgically unresectable patients, creation of human PDA organoids at the time of tissue diagnosis could allow this group of patients to benefit from precision medicine with personalized treatment.
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