111 Outcomes of Patients with Anthracycline Cardiomyopathy Treated with Mechanical Circulatory Support: Data from the INTERMACS Registry

Abstract

cardiac index (p 0.20), inotrope use (p 0.47), loop diuretic use (p 0.55) and diabetes (p 0.9) were not associated with IRF. Pts with an elevated BUN/Cr had significantly increased incidence of IRF (OR 1.5, p 0.001). This association persisted after adjustment for baseline GFR (OR 1.5, p 0.001) and adjustment for baseline characteristics associated with IRF (hemoglobin, heart rate, systolic blood pressure, ACE inhibitor use, beta blocker use, edema, race, INTERMACS class, and sodium; OR 1.5, p 0.002). Conclusions: HF pts with an elevated pre-implant BUN/Cr are more likely to experience post-LVAD IRF. The ability to appropriately distinguish pts with reversible from those with irreversible RI, utilizing markers such as BUN/Cr, could potentially facilitate use of advanced therapies in pts previously not considered candidates due to their RI. Additional research aimed at identification of pts with potential for significant IRF is warranted.