111 Cellular and molecular profiling of early-stage mycosis fungoides in comparison to parapsoriasis and atopic dermatitis reveals disease-specific biomarkers

Abstract

Primary cutaneous T-cell lymphomas (CTCL) are a group of incurable extranodal non-Hodgkin lymphomas that usually develop from skin-homing CD4+ T cells, with mycosis fungoides (MF) as their most frequent entity. Due to clinical and histopathological similarities to benign inflammatory conditions, it takes a median of 3 years from the initial appearance of a skin lesion until a definitive diagnosis of MF can be made, and there are currently no specific diagnostic biomarkers available. To better define cellular and molecular characteristics of CTCL in comparison to its potential imitators, we profiled skin biopsies of early MF vs.