1107P BRAF mutations and fusions in a real-world cohort of NSCLC patients

Abstract

BRAF V600E (class I) mutant non-small cell lung cancer (NSCLC) is well characterized. However, less is known about other classes of BRAF mutations or BRAF fusions in this population. Previous studies have suggested that different classes of BRAF mutations may have varied clinical implications, motivating further study to guide therapeutic options in clinical practice. In this work, we set out to characterize the class of BRAF and co-occurring mutations as well as BRAF fusions in a real-world NSCLC cohort using comprehensive genomic profiling (CGP).