Abstract
High-grade (HG) gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are rare and have poor outcome. Molecular data for HG GEP-NEN is limited and the WHO classification based on morphology and proliferation, while treatment strategies are extrapolated from small-cell lung cancer (SCLC). We aimed to characterize molecular features and relate these to classification, primary site and potential new treatments.
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