Abstract
Cutaneous T-cell lymphoma (CTCL) is a primary non-Hodgkin lymphoma and the most common primary cutaneous lymphoma. Due to its varied clinical and histological presentation, the accurate diagnosis of CTCL is difficult and therefore delayed; in advanced stages, CTCL is incurable and often fatal, though treatment-resistant phenotypes and survival time can be difficult to predict. There remains an unmet need for new and more effective diagnostic and prognostic indicators and novel therapies. To this end, malignant cells were isolated from the peripheral blood of 15 CTCL patients using antibody-magnetic bead or FACS sorting for CD3+CD4+ and CD7- and/or CD26- based on the known aberrant phenotype of the patient or positive selection for CD45RO+ CD4+ T cells in 3 healthy controls.
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