110 Non-invasive molecular analysis for CTCL detection and differentiation from other skin conditions with adhesive smart sticker skin sample collection

Abstract

Cutaneous T cell lymphoma (CTCL) is a complex and heterogenous disease with a range of pathogenic, diagnostic, prognostic and therapeutic courses. Broadly, CTCL is characterized by cutaneous infiltrates of aberrant monocolonal T-lymphocytes. Clinically and histopathologically, CTCL often mimics psoriasis, eczema and other benign dermatoses. Diagnosis of CTCL is often delayed by 4-6 years from the time lesions initially appear, and typically requires multiple skin biopsies and blood tests. In this study, we employed non-invasive adhesive patches to collect samples from lesional skin of CTCL (n=12) and psoriasis (n=10) patients as well as non-lesional skin from healthy (n=12) volunteers.